Heart rate (HR) and heart rate variability (HRV) response to inhaled N, N-dimethyltryptamine (N, N-DMT): A case report

Abstract Background N, N-Dimethyltryptamine (N, N-DMT) is a naturally occurring tryptamine-based alkaloid and classic psychedelic. The potent psychoactive properties of N-DMT are mediated by serotonin 2A (5-HT ) receptor agonism. There limited investigations into the physiologic effects inhaled N-DMT, despite this being one most common routes administration. Heart rate variability (HRV) an emergent non-invasive marker cardiac autonomic nervous system (ANS) regulation reductions in HRV have been negatively associated with multiple health outcomes. Methods A case described brief review supportive findings. Results (HR) responses following three naturalistic experiences were documented healthy 31-year-old male. Acute transient elevations HR immediately administration pronounced elevation average daily one-day observed. duration experience shortened across similar doses. Conclusion These findings offer preliminary evidence effect on HRV. Given understanding as hazardous stress, psychiatric conditions, mental outcomes, further research psychedelics warranted.